L-Citrulline for ED: How Long Does It Take to Work?

What is the duration of action of L-citrulline for ED? We are here to help you understand it.

Given that erectile dysfunction (ED) affects approximately 30 million men worldwide, there are a plethora of treatment options. It can be challenging to choose between natural remedies and oral medications for ED. For personalized advice, you can consult an ED doctor online to help determine the best treatment plan for your needs.

You may be familiar with L-citrulline supplements as an alternative treatment for erectile dysfunction. L-citrulline, an amino acid that the body produces, is changed into another amino acid called L-arginine. To produce L-arginine, which increases blood flow by generating nitric oxide, a gas that aids in blood vessel widening, some people take L-citrulline supplements.

To increase muscle strength or lessen soreness after a strenuous workout, some people may take L-citrulline supplements or L-citrulline malate, which is a form of citrulline that combines L-citrulline with malic acid.

L-citrulline may be used by others to treat ED.

Does L-citrulline help with ED, though? If yes, what is the duration of action of L-citrulline for ED?

L-Citrulline for ED: What the Research Says

What precisely does L-citrulline do, and is taking citrulline supplements a good way to treat erectile dysfunction?

As previously mentioned, L-citrulline changes into L-arginine, which raises the production of nitric acid to dilate blood vessels. Since erection depends on healthy blood flow, L-citrulline may theoretically lessen ED.

Let’s examine erections to learn how L-citrulline may help lessen ED. The corpora cavernosa, a tissue inside your penis, receives a signal from your nervous system when you feel sexually aroused.

An erection is produced when the blood vessels that supply blood to your penis dilate, increasing blood flow.

Nitric oxide, one of the molecules involved in this process, is essential for relaxing the smooth muscle tissue that regulates blood flow to the erectile tissue inside your penis.

The conversion of L-citrulline to L-arginine aids in the synthesis of nitric oxide. People may use L-citrulline supplements to raise their arginine levels and achieve a normal erection because arginine (or even nitric oxide) supplements might not be the most effective way to produce nitric oxide.

L-arginine is sometimes promoted as a natural treatment for erectile dysfunction, but this assertion is not well-supported by research.

Likewise, there is currently very little research on L-citrulline for ED.

An effective treatment for erection hardness scores and overall sexual satisfaction was oral citrulline supplementation, according to a small study involving 24 men with moderate to mild erectile dysfunction.

The effectiveness of oral L-citrulline supplementation in treating ED was also discovered in a small study involving 13 men. The first line of treatment for the majority of men with erectile dysfunction, however, was a combination of citrulline supplementation with a polyphenol called resveratrol and a PDE5 inhibitor.

L-citrulline is thought to be safe, despite the paucity of research on its efficacy for ED. Large-scale randomized clinical trials to evaluate the safety of L-citrulline for the treatment of ED have not yet been conducted.

When standard ED medications don’t work for a man or if he has too many side effects, he may want to try L-citrulline. There are proven treatments for ED, which we’ll discuss below.

However, how long does L-citrulline take to start working for ED? Read on to find out.

How Quickly Does L-Citrulline Work for ED?

The question, “How long does it take for L-citrulline to work for ED?” is unclear because there hasn’t been a large study to evaluate the effects of L-citrulline on ED.

In both of the aforementioned studies, patients received treatment for two months, first taking an inactive medication (a placebo) and then taking oral citrulline supplements for another month.

To completely understand whether oral citrulline supplementation is effective and how long L-citrulline takes to work for erectile dysfunction, more research is required.